Acetazolamide (Altitude Sickness Prevention)

Overview

Acute mountain sickness (AMS) affects 25–85% of unacclimatized travelers above 2,500 meters according to the CDC Yellow Book. Symptoms include headache, fatigue, nausea, and dizziness, and can progress to life-threatening conditions such as high-altitude pulmonary or cerebral edema if left untreated.

Acetazolamide works by inhibiting carbonic anhydrase, which stimulates faster, deeper breathing and accelerates acclimatization. According to CDC guidelines, it's typically started 1–2 days before ascent and continued for 2 days after reaching the highest sleeping elevation.

The FDA-approved labeling notes the most commonly reported side effects include tingling in the hands and feet (paresthesias), increased urination, and altered taste of carbonated beverages. The CDC considers it the most evidence-based pharmacological option for AMS prevention.

Wandr Health vs. a traditional travel clinic

Other travel medications

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