Altitude Sickness

Acetazolamide (Altitude Sickness Prevention)

Oral tablet · Up to 60 travel days

Acetazolamide (Diamox) is the CDC-recommended medication for prevention of acute mountain sickness (AMS) in travelers ascending to elevations above 2,500 meters (8,200 feet). Through Wandr Health, it's available from $89 — no appointment needed. No appointment needed.

Overview

Acute mountain sickness (AMS) affects 25–85% of unacclimatized travelers above 2,500 m (CDC Yellow Book). Acetazolamide inhibits carbonic anhydrase to accelerate acclimatization and is the CDC's most evidence-based option for AMS prevention. It's typically started 1–2 days before ascent and continued for 2 days after reaching peak elevation.

Common side effects include tingling in the hands and feet, increased urination, and altered taste of carbonated beverages. Acetazolamide is a sulfonamide derivative and should be avoided by individuals with sulfa allergies.

Sources: CDC Yellow Book 2026; Wilderness Medical Society guidelines; FDA prescribing information

Wandr Health vs. a traditional travel clinic

Wandr Health
Travel Clinic
Provider visit$89+$200+
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AppointmentNone neededRequired
Follow-upUnlimited messagingNew appointment

Other travel medications

When travelers use this

  • Treks above 8,000 feet including Machu Picchu, Kilimanjaro, Everest Base Camp, and Colorado ski towns
  • Travelers flying directly to high-altitude cities like Cusco, La Paz, or Lhasa
  • Adventure travelers and hikers who want preventive coverage against acute mountain sickness

Related guides

Frequently asked questions

Medical disclaimer
This page is for educational and informational purposes only and does not constitute medical advice. All treatment decisions are made by a licensed provider based on your individual health profile.
$89
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Medically reviewed by the Wandr Health Medical Team · Last updated March 30, 2026
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