Atovaquone-Proguanil (Malarone)
Atovaquone-Proguanil (generic Malarone) is one of the most widely prescribed antimalarials for international travelers. According to the CDC, malaria transmission occurs in approximately 95 countries, and prophylaxis is recommended for nearly all travelers to sub-Saharan Africa, parts of South America, and Southeast Asia. Through Wandr Health, it's available for $134 with free shipping. No appointment needed.
Where is this medication recommended?
Search your destination or explore the map. Countries highlighted by the CDC's malaria risk classification.
Overview
Atovaquone-Proguanil is a combination antimalarial used for prevention in travelers to endemic regions. It targets the malaria parasite at both blood and liver stages. The WHO reported 263 million malaria cases globally in 2023, concentrated primarily in sub-Saharan Africa.
According to CDC guidelines, it's typically started 1–2 days before entering a risk area, taken daily, and continued for 7 days after departure — a significantly shorter post-travel course than alternatives requiring 28 days.
The FDA-approved labeling notes the most commonly reported side effects include nausea, stomach pain, and headache. The CDC considers it to have fewer neuropsychiatric side effects compared to some alternatives.
Wandr Health vs. a traditional travel clinic
Other travel medications
Frequently asked questions
Atovaquone-Proguanil · $134 + $25 fee · Free shipping
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