Atovaquone-Proguanil (Malarone)
Atovaquone-Proguanil (generic Malarone) is one of the most widely prescribed antimalarials for international travelers. According to the CDC, malaria transmission occurs in approximately 95 countries, and prophylaxis is recommended for nearly all travelers to sub-Saharan Africa, parts of South America, and Southeast Asia. Through Wandr Health, it's available from $89 — no appointment needed.
Where is this medication recommended?
Search your destination or explore the map. Countries highlighted by the CDC's malaria risk classification.
Overview
Atovaquone-Proguanil is a CDC-recommended antimalarial that targets the parasite at both blood and liver stages. Started 1–2 days before entering a risk area and continued for just 7 days after — significantly shorter than the 28-day course required by some alternatives.
Common side effects include nausea, stomach pain, and headache. The CDC considers it to have fewer neuropsychiatric side effects compared to alternatives like mefloquine.
Wandr Health vs. a traditional travel clinic
Other travel medications
When travelers use this
- Trips to malaria-endemic regions in sub-Saharan Africa, Southeast Asia, or South America
- Short-term travelers who prefer a medication they can stop 7 days after leaving the area
- Travelers who cannot tolerate doxycycline (sun sensitivity) or mefloquine (neuropsychiatric risk)
- Business and leisure travelers seeking the best-tolerated antimalarial