Atovaquone-Proguanil (Malarone)
Atovaquone-Proguanil (generic Malarone) is one of the most widely prescribed antimalarials for international travelers. According to the CDC, malaria transmission occurs in approximately 95 countries, and prophylaxis is recommended for nearly all travelers to sub-Saharan Africa, parts of South America, and Southeast Asia. Through Wandr Health, a US-licensed provider reviews your request in an $89 online visit — no appointment needed — and sends the prescription to the pharmacy you choose.
Where is this medication recommended?
Search your destination. Countries highlighted by the CDC's malaria risk classification.
Overview
Atovaquone-Proguanil is a CDC-recommended antimalarial that targets the parasite at both blood and liver stages. Started 1–2 days before entering a risk area and continued for just 7 days after — significantly shorter than the 28-day course required by some alternatives.
Common side effects include nausea, stomach pain, and headache. The CDC considers it to have fewer neuropsychiatric side effects compared to alternatives like mefloquine.
Wandr Health vs. a traditional travel clinic
Trips where travelers use Atovaquone-Proguanil
Other travel medications
When travelers use this
- Trips to malaria-endemic regions in sub-Saharan Africa, Southeast Asia, or South America
- Short-term travelers who prefer a medication they can stop 7 days after leaving the area
- Travelers who cannot tolerate doxycycline (sun sensitivity) or mefloquine (neuropsychiatric risk)
- Business and leisure travelers seeking the best-tolerated antimalarial
Related guides
Frequently asked questions
A Wandr Health provider visit is $89 and covers the licensed provider review, personalized recommendations, and prescription. Your prescription is sent to your preferred pharmacy, where you pay for the medication separately. At a traditional travel clinic, a consultation fee of $75–$150 typically applies on top of the medication cost.
The CDC notes that Atovaquone-Proguanil should be started 1–2 days before entering a malaria-risk area. We recommend completing your intake at least 1 week before departure to allow time for the provider review (typically within 24 hours) — prescriptions are usually ready for same-day pickup.
Malarone is the brand name manufactured by GlaxoSmithKline. Generic Atovaquone-Proguanil contains the same active ingredients at the same doses and is FDA-approved as therapeutically equivalent. Wandr Health provides the generic version at a significantly lower cost.
Yes. The CDC lists Atovaquone-Proguanil as one of the primary antimalarials recommended for travelers to areas with chloroquine-resistant malaria, which includes most endemic regions. (Source: CDC Yellow Book 2026)