Traveler's Diarrhea

Ciprofloxacin (Traveler's Diarrhea)

Oral tablet · 1 treatment course

Ciprofloxacin is a fluoroquinolone antibiotic and one of the CDC's recommended options for self-treatment of traveler's diarrhea acquired in most regions outside South and Southeast Asia. Through Wandr Health, a treatment course is available from $89 — no appointment needed. No appointment needed.

Overview

Ciprofloxacin is the CDC's primary recommendation for traveler's diarrhea in Africa, Central/South America, and the Middle East. It targets enterotoxigenic E. coli, Salmonella, and Shigella, and is typically taken as a single 750 mg dose or 500 mg twice daily for 1–3 days.

For South and Southeast Asia, Azithromycin is preferred due to rising fluoroquinolone resistance. The CDC recommends self-treatment when diarrhea is incapacitating or accompanied by fever or bloody stools.

Sources: CDC Yellow Book 2026; FDA prescribing information

Wandr Health vs. a traditional travel clinic

Wandr Health
Travel Clinic
Provider visit$89+$200+
Your timeUnder 10 minutesHours in a waiting room
AppointmentNone neededRequired
Follow-upUnlimited messagingNew appointment

Other travel medications

When travelers use this

  • Trips to Africa, Central/South America, or the Middle East where TD risk is moderate to high
  • Travelers who want a self-treatment option on hand for moderate-to-severe diarrhea
  • Business travelers or those on tight itineraries who cannot afford days of illness
  • Backpackers, adventure travelers, and cruise passengers visiting multiple ports

Compare with Azithromycin

The CDC recommends Azithromycin over Ciprofloxacin for travelers to South and Southeast Asia due to higher fluoroquinolone resistance rates. For all other regions, Ciprofloxacin remains a first-line option.

View Azithromycin

Related guides

Antibiotic stewardship

Wandr Health follows CDC guidelines for responsible antibiotic prescribing. All antibiotic prescriptions are reviewed by a licensed provider who evaluates appropriateness based on your destination and health profile.

Read our stewardship policy →

Frequently asked questions

Medical disclaimer
This page is for educational and informational purposes only and does not constitute medical advice. All treatment decisions are made by a licensed provider based on your individual health profile.
$89
Provider visit · Rx sent to your pharmacy
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Answer a few health questions. A licensed provider reviews and recommends treatment.
Licensed provider review included
Same-day pharmacy pickup
HSA/FSA eligible
Unlimited provider messaging
How it works
1
Answer a few questions about your trip
2
A provider reviews and recommends treatment
3
If prescribed, it's sent to a pharmacy near you
Questions?
Our care team can help with travel medication questions.
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Medically reviewed by the Wandr Health Medical Team · Last updated March 30, 2026
Same-day reviewFully onlineHIPAA compliant
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