Siem Reap · Angkor · Travel Medicine
The temples are inside the malaria zone. Pack the pill before you fly.
One Rx of atovaquone-proguanil before the flight to Siem Reap, plus hydroxyzine for the jet lag and ondansetron for the off day. Ready at your pharmacy at home, in your day pack by the time the tuk-tuk pulls up at Angkor Wat for sunrise.
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The CDC places almost all of Cambodia inside the malaria-risk zone, with the only meaningful exceptions being Phnom Penh and the immediate area around Tonle Sap. Angkor Wat and the wider temple circuit sit inside that zone. Mefloquine resistance is widespread in the western provinces and chloroquine resistance is countrywide, which is why the CDC's first-line prophylaxis for Cambodia is atovaquone-proguanil. The 20-plus hours of flying through Doha or Singapore, the 11 to 14 hour jet lag, and the 4 a.m. tuk-tuk to catch sunrise at the main temple stack the first three nights of the trip in a way that hydroxyzine is well-suited to manage. Carrying ondansetron rounds it out for the food-related nausea most travelers eventually meet in Southeast Asia.
Cambodia travel health guide — vaccines, snapshot overview, and what to review before you go.
Orders are reviewed and prescriptions sent to your pharmacy within 24 hours.
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Medications in the Siem Reap & Angkor Wat plan
Cambodia travel medication FAQ
- Siem Reap city is low-risk, and Phnom Penh and the immediate area around Tonle Sap are explicitly outside the CDC's malaria risk map for Cambodia. But the wider Angkor temple complex sits in forested countryside, and almost every other province a traveler is likely to visit, Banteay Meanchey, Battambang, Pailin, Preah Vihear, Mondulkiri, Ratanakiri, Stung Treng, is inside the risk zone. The conservative call is to take prophylaxis if your trip includes anything beyond city hotels and the main temple stack, especially overnight stays outside Siem Reap. Atovaquone-proguanil is CDC first-line for Cambodia because chloroquine resistance is countrywide and mefloquine resistance is widespread in the west.
- One tablet by mouth daily, taken with food or a milky drink to improve absorption. Start 1 to 2 days before you enter the malaria area, continue every day you are there, and keep taking it for 7 days after you leave. The short pre-trip and post-trip window is the reason this is the preferred pill for shorter Cambodia itineraries; doxycycline requires 4 weeks of dosing after the trip, which is a significant difference for travelers with a 10 to 14 day Cambodia plan.
- Three prescriptions in one visit. Atovaquone-proguanil (Malarone) for malaria prevention while you are in country. Hydroxyzine (Vistaril) for the sleep and travel anxiety load that comes with a 20-plus hour flight chain through Doha, Dubai, or Singapore plus the 11 to 14 hour jet lag. The first three nights in Siem Reap are where this matters most, especially when 4 a.m. tuk-tuks for sunrise temple visits are on the itinerary. Ondansetron (Zofran) for food-related nausea, which is the second most common medical complaint travelers bring back from Southeast Asia after diarrhea itself. Three risks, three prescriptions, one visit.
- Orders are reviewed by a US-licensed provider and the Rx is sent electronically to your pharmacy within 24 hours. Most travelers can pick it up the same day.
- After your provider approves the Rx, it's sent electronically to whichever pharmacy you choose during your visit. Your pharmacy will tell you when the medication is ready for pickup. You can use your pharmacy insurance to cover the medication itself.
- If a provider can't safely prescribe (rare, usually due to a contraindication), the visit fee is refunded in full. You only pay if the Rx is sent.
See Angkor at sunrise with the prescriptions already in your pack.
One visit, three prescriptions for the malaria zone, the jet lag, and the off day. Reviewed by a US-licensed provider, ready at your pharmacy before you fly to Siem Reap.